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崔曉峰

發布時間:2019.01.21 10:00

   

  

   姓名:崔曉峰    

  性別:    

  出生年月:  

  學位:博士    

  職稱:武漢理工大學化學化工與生命科學學院教授、博士生導師、德國慕尼黑工業大學講座教授、美國倫斯勒理工大學兼職教授 

  聯系電話:      

  Emailxfcui@whut.edu.cn xfc.cui@gmail.com 

    

  教育經歷: 

  2004/5-2008/12 美國克萊姆森大學生物醫學工程系,博士 

  2001/8-2004/5 美國克萊姆森大學材料科學與工程系,碩士 

  1994/09-1998/07 華東理工大學生化工程系,學士 

  工作經歷: 

  2015-至今 德國慕尼黑工業大學,講座教授 

  2014-至今 武漢理工大學化學化工與生命科學學院,教授、博士生導師 

  2013-2018 美國倫斯勒理工大學生物技術交叉學科研究中心,兼職教授 

  2013-2014 美國斯特摩根公司,首席科學家,研發總監 

  2010-2013 美國斯克里普斯研究所,資深科學家 

  2009-2010 美國斯克利普斯研究所,博士后研究員 

  研究領域: 

  生物材料;生物3D打??;高通量藥敏檢測和藥物篩選;干細胞研究和應用;關節軟骨、半月板、骨骼與肌肉的組織工程;生物傳感器;器官芯片。 

  招收研究生博士生方向:生物技術、藥學、生物材料、生物醫學工程、醫學、高分子化學等 

  課題組長期招收博士后、博士生、研究生 

主要科研項目: 

1. 國家自然科學基金青年科學基金項目:生物打印復合材料和干細胞在半月板組織工程中的應用和機理研究,01/01/2019-12/31/2021

2. 湖北省科學技術廳一般面上項目:運用生物3D打印技術構建半月板組織工程產物,03/2018-03/2020

3. 基于3D打印的毛囊化皮膚模型的構建和應用基礎研究,中央高?;究蒲谢A學科重點項目,01/2017-12/2018

4. 生物3D打印平臺的建設,企業委托,01/2017-12/2018

5. 武漢理工大學第二輪“15551人才工程”青年拔尖人才第一層次,12/2016-11/2021

6. 武漢理工大學2017ESI面上項目-材料科學,01/2017-12/2017

7. 半月板增材組織制造的研究,中央高?;究蒲谢A學科重點項目,01/2015-12/2016

代表性論文與專利:

作為世界上最早開始研究生物3D打印和細胞生物打印的專家學者,崔教授曾成功打印出世界上首例具有生理功能的人毛細血管網,該工作發表在生物材料領域頂級期刊Biomaterials上。在美國頂級生物醫學研究單位斯克利普斯研究所打印出世界首例達到人關節軟骨各項指標的生物活性軟骨組織,該工作榮獲第十屆國際軟骨修復學會最佳論文獎(500篇論文中的第一名)和美國斯克利普斯研究所杰出貢獻獎。崔教授亦曾先后獲得國際骨科研究學會著名研究員獎、國際軟骨修復學會優秀論文獎、美國生物材料學會杰出貢獻獎、美國國家紡織中心主席獎、美國政府杰出海外人士、入選美國名人錄等榮譽。在生物3D打印、智能生物材料、干細胞研究和應用、血管構建、生物反應器、高通量藥物篩選、關節軟骨、半月板、骨骼和肌肉的組織工程等研究領域發表高水平學術期刊與會議論文數十篇,同行論文引用超過3500次以上,H-index 21。崔教授現在擔任歐盟基金會評委、澳大利亞國家基金理事會評委、法國牙科研究學會基金評委、中國工程院“中國3D打印材料及應用發展戰略研究”特聘專家、五十余種國際學術期刊的審稿專家。曾受邀親自參加美國探索頻道關于生物3D打印專題節目的錄制拍攝,接受已有近40年歷史的美國老牌科學雜志GEN的專訪,其研究工作被美國CNN、FOX等國家新聞網廣泛報道。并受邀在國際學術會議和世界著名大學(包括普林斯頓大學、杜克大學、德州大學MD安德森癌癥醫學中心、加州大學等)做學術報告30余次。

1. Ming Li, Chuang Ma, Xiong Liu, Jun Su, Xiaofeng Cui, Yunbin He. Synthesis of a 2D phosphorus material in a MOF-based 2D nano-reactor. Chemical Science, 2018 June; 9(27):5912-5918. doi: 10.1039/c8sc01439f (IF: 9.063, 中科院SCI 1)

2. Riho Kurata#, Asuka Kumagai#, Xiaofeng Cui#, Masamitsu Harada, Jun Nagai, Yasuhiro Yoshida, Kei-ichi Ozaki, Yoshimasa Tanaka, Tomo Yonezawa. Establishment of novel reporter cells stably maintaining transcription factor-driven human secreted alkaline phosphatase expression. Current Pharmaceutical Biotechnology, 2018; 19(3):224-231. doi: 10.2174/1389201019666180418093334 (共同一作,IF: 1.819,SCI)

3. Guifang Gao, Ying Huang, Arndt F. Schilling, Karen Hubbell, Xiaofeng Cui*. Organ Bioprinting: Are We There Yet? Advanced Healthcare Materials, 2018 Jan; 7(1). doi: 10.1002/adhm.201701018 (通訊作者,IF: 5.609, 中科院SCI 1)

4. Xiaofei Zhang, Jun Li, Pengxiang Ye, Guifang Gao, Xiaofeng Cui*. Coculture of mesenchymal stem cells and endothelial cells enhances host tissue integration and epidermis maturation through AKT activation in GelMA hydrogel-based skin model. Acta Biomaterialia, 2017 Sep; 59:317-326. doi: 10.1016/j.actbio.2017.07.001 (通訊作者,IF: 6.383, 中科院SCI 1)

5. Ying Huang, Xiao-Fei Zhang, Guifang Gao, Tomo Yonezawa, Xiaofeng Cui*. 3D Bioprinting and the Applications in Tissue Engineering. Biotechnology Journal, 2017 Aug; 12(8). doi: 10.1002/biot.201600734 (通訊作者,IF: 3.507, JCR 1)

6. Xiaofei Zhang, Rongfu Tu, Keke Li, Pengxiang Ye, Xiaofeng Cui*. Tumor Suppressor PRPRJ is a Target of miR-155 in Colorectal Cancer. Journal of Cellular Biochemistry, 2017 Oct; 118(10):3391-3400. doi: 10.1002/jcb.25995 (通訊作者,IF: 2.959, 中科院SCI 2)

7. Xiaofei Zhang, Xiaofeng Cui*. Connexin 43: Key Roles in the Skin. Biomedical Reports, 2017 Jun; 6(6):605-611. doi: 10.3892/br.2017.903 (通訊作者)

8. Guifang Gao, Xiao-Fei Zhang, Karen Hubbell, Xiaofeng Cui*. NR2F2 Regulates Chondrogenesis of Human Mesenchymal Stem Cells in Bioprinted Cartilage. Biotechnology and Bioengineering, 2017 Jan; 114(1):208-216, 2017. doi: 10.1002/bit.26042 (通訊作者,IF: 3.952, 中科院SCI 1)

9. Xiaofeng Cui, Yao Wei Lu, Vivian Lee, Diana Kim, Taylor Dorsey, Qingjie Wang, Young Lee, Peter Vincent, John Schwarz, Guohao Dai. Venous Endothelial Marker COUP-TFII Regulates the Distinct Pathologic Potentials of Adult Arteries and Veins. Scientific Reports, 2015 Nov; 5:16193. doi: 10.1038/srep16193 (IF: 4.122, SCI ,Nature子刊)

10. Guifang Gao, Xiaofeng Cui*. Three-dimensional Bioprinting in Tissue Engineering and Regenerative Medicine. Biotechnology Letters, 2016 Feb; 38(2):203-211. doi:10.1007/s10529-015-1975-1 (通訊作者,IF: 1.846, SCI)

11. Guifang Gao, Arndt F. Schilling, Karen Hubbell, Tomo Yonezawa, Danh Truong, Yi Hong, Guohao Dai, Xiaofeng Cui*. Improved Properties of Bone and Cartilage Tissue from 3D Inkjet-bioprinted Human Mesenchymal Stem Cells by Simultaneous Deposition and Photocrosslinking in PEG-GelMA. Biotechnology Letters, 2015 Nov; 37(11):2349-2355. doi: 10.1007/s10529-015-1921-2 (通訊作者,IF: 1.846, SCI)

12. Guifang Gao, Tomo Yonezawa, Karen Hubbell, Guohao Dai, Xiaofeng Cui*. Inkjet-bioprinted acrylated peptides and PEG hydrogel with human mesenchymal stem cells promote robust bone and cartilage formation with minimal printhead clogging. Biotechnology Journal, 2015 Oct; 10(10):1568-1577. doi: 10.1002/biot.201400635 (通訊作者,IF: 3.507, JCR 1)

13. Guifang Gao, Arndt F. Schilling, Tomo Yonezawa, Jiang Wang, Guohao Dai, Xiaofeng Cui*. Bioactive Nanoparticles Stimulate Bone Tissue Formation in Bioprinted Three-Dimensional Scaffold and Human Mesenchymal Stem Cells. Biotechnology Journal, 2014 Oct; 9(10):1304-1311. doi: 10.1002/biot.201400305 (通訊作者,IF: 3.507, JCR 1)

14. Xiaofeng Cui*, Guifang Gao, Tomo Yonezawa, Guohao Dai. Human Cartilage Tissue Fabrication Using Three-Dimensional Inkjet Printing Technology. JOVE-Journal of Visualized Experiments, 2014 Jun; (88), e51294. doi: 10.3791/51294 (IF: 1.184, SCI)

15. Riho Kurata, Xiaofeng Cui, Roh Saug-gun, Tomo Yonezawa. Supplementation of Long-Chain Fatty Acids with lactating Mammary Glands and Beef Cow has Potential Benefits. Advances in Plants and Agriculture Research, 2015. doi: 10.15406/apar.2015.02.00063

16. Tomo Yonezawa T, Riho Kurata, Atsushi Tajima, Xiaofeng Cui, Hiroki Maruta, Hirofumi Nakaoka, Keiichi Nakajima, Hidetoshi Inoko. Comparative Proteomics and Network Analysis Identify PKC Epsilon Underlying Long-Chain Fatty Acid Signaling. Journal of Proteomics and Bioinformatics, 2014; 7(11):340-346 (IF: 2.56)

17. Tomo Yonezawa, Riho Kurata, Kaori Yoshida, Masanori A. Murayama, Xiaofeng Cui, Akihiko Hasegawa. Free Fatty Acids-Sensing G Protein-Coupled Receptors in Drug Targeting and Therapeutics. Current Medicinal Chemistry, 2013; 20(31):3855-3871. doi: 10.2174/09298673113209990168 (IF: 3.469, SCI A )

18. Xiaofeng Cui*, Guifang Gao, Yongjun Qiu. Accelerated Myotube Formation Using Bioprinting Technology for Biosensor Applications. Biotechnology Letters, 2013 Mar; 35(3):315-321. doi:10.1007/s10529-012-1087-0 (IF: 1.846, SCI)

19. Xiaofeng Cui, Kurt Breitenkamp, Martin Lotz, Darryl DLima. Synergistic Action of FGF-2 and TGF-β1 Enhances Bioprinted Human Neocartilage Formation. Biotechnology and Bioengineering, 2012 Sep; 109(9):2357-2368. doi: 10.1002/bit.24488 (IF: 3.952, SCI 1)

20. Xiaofeng Cui*, Akihiko Hasegawa, Martin Lotz, Darryl D’Lima. Structured 3D Co-culture of Mesenchymal Stem Cells with Meniscus Cells Promotes Meniscal Phenotype without Hypertrophy. Biotechnology and Bioengineering, 2012 Sep; 109(9):2369-2380. doi: 10.1002/bit.24495 (IF: 3.952, SCI 1)

21. Xiaofeng Cui*, Thomas Boland, Darryl D. D’Lima, Martin K. Lotz. Thermal Inkjet Printing in Tissue Engineering and Regenerative Medicine. Recent Patents on Drug Delivery and Formulation, 2012 Aug; 6(2):149-155. doi:10.2174/187221112800672949 (IF: 2.46)

22. Xiaofeng Cui, Kurt Breitenkamp, M.G. Finn, Martin Lotz, Darryl D. D’Lima. Direct Human Cartilage Repair Using 3D Bioprinting Technology. Tissue Engineering Part A, 2012 June; 18(11-12):1304-1312. doi: 10.1089/ten.TEA.2011.0543 (Reported on Science) (IF: 4.448, SCI A)

23. Xiaofeng Cui*, Michael Ellison. Effects of Biodiesel Waste Glycerol on the Growth Characteristics of Pichia pastoris Genetically Modified to Produce Spidroin. International Journal of ChemTech Research, 2012; 4(2):713-9.

24. Xiaofeng Cui*, Kurt Breitenkamp, M.G. Finn, Martin Lotz, Clifford W. Colwell. Direct Human Cartilage Repair Using Thermal Inkjet Printing Technology. Osteoarthritis and Cartilage, 2011 Sep; 19:S47-48. (IF: 5.454, SCI 1)

25. Xiaofeng Cui*, Delphine Dean, Zaverio M. Ruggeri, Thomas Boland. Cell Damage Evaluation of Thermal Inkjet Printed Chinese Hamster Ovary Cells. Biotechnology and Bioengineering, 2010 Aug; 106(6):963-969. doi: 10.1002/bit.22762 (IF: 3.952, SCI 1)

26. Bas de Laat, Xiaofeng Cui, Jennifer Nagrampa-Orje, Mariko Yabe, James R Roberts, Zaverio M Ruggeri, Biomechanical Properties of the Glycoprotein Ib-von Willebrand Factor Interaction under Flow. Circulation, 2009 Nov; 120(18):S1169. (IF: 18.880, SCI 1)

27. Xiaofeng Cui, Thomas Boland. Human Microvasculature Fabrication Using Thermal Inkjet Printing Technology. Biomaterials, 2009 Oct; 30(31):6221-6227. doi: 10.1016/j.biomaterials (IF: 8.806, SCI 1)

28. Changhong Zhang, Kejia Zhao, Tianyi Hu, Xiaofeng Cui, Nathan Brown, Thomas Boland. Loading Dependent Swelling and Release Properties of Novel Biodegradable, Elastic and Environmental Stimuli-sensitive Polyurethanes, Journal of Controlled Release, 2008 Oct; 131(2):128-136. doi: 10.1016/j.jconrel.2008.07.026 (IF: 7.877, SCI 1)

29. Xiaofeng Cui, Thomas Boland, Simultaneous Deposition of Human Microvascular Endothelial Cells and Biomaterials for Human Microvasculature Fabrication Using Inkjet Printing, NIP24/digital Fabrication 2008: 24th International Conference on Digital Printing Technologies, Technical Program and Proceedings, 2008; 24:480-483.

30. Sandra Deitch, Catherine Kunkle, Xiaofeng Cui, Thomas Boland, Delphine Dean. Collagen Matrix Alignment Using Inkjet Printer Technology, Materials Research Society Symposium Proceedings, 2008; 1094:DD07-16

31. Nripen Singh, Xiaofeng Cui, Thomas Boland, Scott M. Husson. The Role of Independently Variable Grafting Density and Layer Thickness of Polymer Nanolayers on Peptide Adsorption and Cell Adhesion, Biomaterials, 2007 Feb; 28(5):763-771. doi: 10.1016/j.biomaterials.2006.09036 (IF: 8.806, SCI 1)

32. Thomas Boland, Xiaofeng Cui, Aditya Chaubey, Timothy C. Burg, Richard E. Groff, Karen J. L. Burg, Precision Printing of Cells and Biomaterials onto 3D Matrices, Proceedings of the ASME International Conference on Manufacturing Science and Engineering, 2007; MSEC2007 (31023):77-81

33. Thomas Boland, Xiaofeng Cui, Michael Aho, Catalin Baicu, Michael Zile. Image Based Printing of Structured Biomaterials for Realizing Complex 3D Cardiovascular Constructs, Journal of Imaging Science and Technology, 2006; 2:86-88 (SCI)

34. Thomas Boland, Tao Xu, Brook Damon, Xiaofeng Cui. Application of Inkjet Printing to Tissue Engineering, Biotechnology Journal, 2006 Sep; 1(9):910-917. doi:10.1002/biot.200600081  (IF: 3.446, JCR 1)

35. Tao Xu, Cassie A. Gregory, Peter Molnar, Xiaofeng Cui, Sahil Jalota, Sarit B. Bhaduri, Thomas Boland. Viability and Electrophysiology of Neural Cell Structures Generated by the Inkjet Printing Method, Biomaterials, 2006 Jul; 27(19):3580-3588. doi:10.1016/i.biomaterials.2006.01.048  (IF: 8.557, SCI 1)

36. Nripen Singh, Scott M. Husson, Xiaofeng Cui, Thomas Boland. Polymer Brush Layers with Variation of Grafting Density for Peptide Adsorption and Cell Adhesion Studies, Abstracts of Papers of the American Chemical Society, 2006; 231:418-PMSE (SCI)

37. Guifang Gao, Karen Hubbell, Arndt F. Schilling, Guohao Dai, Xiaofeng Cui*. Bioprinting Cartilage Tissue from Mesenchymal Stem Cells and PEG Hydrogel. Methods in Molecular Biology, 1612:391-398. doi: 10.1007/978-1-4939-7021-6_28. Editor: Zuzana Koledova. Springer. 2017

38. Xiao-Fei Zhang, Ying Huang, Guifang Gao, Xiaofeng Cui*. Current Progress in Bioprinting. Advances in Biomaterials for Biomedical Applications. Editors: Anuj Tripathi and Jose Savio Melo. Springer Science+Business Media Singapore Pte Ltd. 2016

39. Xiaofeng Cui*. Three-dimensional Bioprinting in Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Series Editor: Kursad Turksen. Springer. 2015

40. Xiaofeng Cui*. Synthetic and Natural Polymers as Bioink for Printed Biomaterials. Printed Biomaterials. Editors: Lee YS, Narayan R, Boland T. Springer. 2010

  學術獎勵及榮譽 

  2016國際軟骨修復學會優秀論文獎 

  2014美國名人錄 

  2012國際軟骨修復學會最佳論文獎(國際大會最高獎項,500篇論文中唯一獲獎者) 

  2012美國斯克利普斯研究院杰出貢獻獎 

  2012國際軟骨修復學會世界大會獎學金 

  2012國際骨科研究學會著名研究員獎 

  2012美國政府杰出海外人士 

  2009國際生物材料學會杰出貢獻獎 

  2008美國真空學會Dorothy M. & Earl S. Hoffman 

  2005美國國家紡織中心主席獎 

  主要學術兼職: 

  美國國立衛生總署(NIH)、美國國家科學基金會(NSF)、歐盟委員會 (European Commission)、澳大利亞國家基金理事會(NHMRC)、法國牙科研究學會(IFRO)基金評委;中國工程院“中國3D打印材料及應用發展戰略研究”特聘專家

  學術期刊評審專家: 

  ACS Applied Materials & Interfaces、ACS Biomaterials Science & Engineering、Acta Biomaterialia、Advanced Biosystems、Advanced Functional Materials、Advanced Healthcare Materials、Advanced Materials、Advanced Therapeutics、Advances in Materials Science and Engineering、Annals of Biomedical Engineering、Applied Materials Today、Biofabrication、Biomaterials、Biomedical Materials、Bioprinting、Biotechnology and Bioengineering、Biotechnology Journal、Biotechnology Progress、Composites Part B、Current Medicinal Chemistry、Current Pharmaceutical Biotechnology、Drug Discovery Today、European Medical Journal、Future Medicine、International Journal of Heat and Mass Transfer、Life Sciences、Journal of Biomedical Materials Research、Journal of Cell Science & Therapy、Journal of Medical Case Reports、Journal of Nutrition & Food Sciences、Journal of Regenerative Medicine、Journal of the American Pharmacists Association、Journal of the Mechanical Behavior of Biomedical Materials、Journal of Tissue Science and Engineering、Journal of Trauma and Treatment、Journal of Stem Cell Research & Therapy、Journal of Visualized Experiments、Materials & Design、Oncology Letters、Regenerative Medicine、Scientific Reports、Small、Stem Cells International、Tissue Engineering、Trends in Biotechnology

 

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